Custom peptides have a wide range of applications, especially in the medical and drug development fields. Hundreds of studies are currently ongoing, concerning these applications, and there are several bundles of research underway, designed to determine other possible uses of custom peptides.
Below is a brief look into some of the top applications of peptides synthesis, highlighting Canadian efforts:
In cancer immunotherapy, the body’s own system is used to fight cancerous cells. Currently, there are peptide-based vaccines, which use tumor-associated antigens, associated with T-cells being used to fight cancer. A lot of research is still ongoing in this field, and based on the results obtained so far, the use of custom peptides to tame the growth and spreading of cancerous cells, looks convincing so far.
These are short, synthetic peptides with amphipathic sequences. They have the ability to spontaneously self-assemble in an aqueous solution, leading to the formation of organized structures like those seen in hydrogels.
These peptides can vary in length and complexity. As such, their synthesis requires a combination of recombinant and chemical synthesis. Bioactive peptides are usually the predominant component present in animal venoms.
Natriuresis is the process by which large amounts of sodium are excreted throughthe urine. These peptides cause the induction of natriuresis, and they have been described as important biomarkers in the process of treating personalized heart failures. They are also involved in maintaining heart volume and pressure, in addition to regulating cardiovascular remodeling pathways.
Bioactive Milk Peptides
Other than its nutritional benefits, milk is a renowned source of peptides and therapeutic proteins, which comes with a variety of functions, including antioxidants, antimicrobial, antiviral, antihypertension, and immunostimulant properties.
The continued prevalence of antibiotic-resistant microbes has been a great hindrance to the treatment of a wide variety of diseases. Through custom peptide synthesis, it is now possible to create anti-microbial drugs, used to combat the antibiotic-resistant microbes.